Abrupt discontinuation of clonidine can cause which rebound effect?

• A. Rapid increase in blood pressure
• B. Hypotension
• C. Weight gain
• D. Bradycardia

Answer: (A)

Abrupt stopping of clonidine leads to rebound hypertension because the drug works by dampening sympathetic outflow through alpha-2 receptors in the brain. When the medication is suddenly discontinued, that suppression is removed and the sympathetic system can surge again, causing a rapid increase in blood pressure. Tachycardia and related symptoms like headaches or anxiety may accompany this surge, making a sudden rise in blood pressure the hallmark rebound effect.

This isn’t consistent with hypotension or a slow heart rate, which would oppose the typical withdrawal pattern. Weight gain isn’t a primary rebound symptom of clonidine discontinuation. To prevent this rebound, clonidine should be tapered rather than stopped abruptly.