What is the mechanism of action of bupropion?

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Multiple Choice

What is the mechanism of action of bupropion?

Explanation:
Bupropion works mainly by blocking the reuptake of dopamine and norepinephrine, increasing their levels in the synapse. This enhances dopaminergic and noradrenergic signaling, which helps improve mood and reduce withdrawal and cravings, supporting its use as an antidepressant and in smoking cessation. Serotonin reuptake inhibition isn’t its primary action, so that option doesn’t capture how the drug works. It does have some activity at nicotinic receptors, which can contribute to reducing nicotine cravings, but the dominant effect is inhibition of dopamine and norepinephrine reuptake. It is not an opioid receptor partial agonist.

Bupropion works mainly by blocking the reuptake of dopamine and norepinephrine, increasing their levels in the synapse. This enhances dopaminergic and noradrenergic signaling, which helps improve mood and reduce withdrawal and cravings, supporting its use as an antidepressant and in smoking cessation. Serotonin reuptake inhibition isn’t its primary action, so that option doesn’t capture how the drug works. It does have some activity at nicotinic receptors, which can contribute to reducing nicotine cravings, but the dominant effect is inhibition of dopamine and norepinephrine reuptake. It is not an opioid receptor partial agonist.

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