What is the recommended approach for initiating smoking cessation in a patient who has never tried pharmacotherapy?

• A. Begin with pharmacotherapy immediately; no counseling necessary.
• B. Begin with counseling and consider first-line pharmacotherapy (NRT, varenicline, or bupropion) based on patient factors; provide quit plan.
• C. Avoid pharmacotherapy for first-time quitters.
• D. Only use varenicline as first-line.

Answer: (B)