Which adverse effect is notably associated with nicotine nasal spray?

• A. Moderate to severe nasal irritation
• B. Headache
• C. Nausea
• D. Minor throat irritation

Answer: (A)

When a medication is delivered as a nasal spray, the nicotine and the spray’s solvents come into direct contact with the nasal lining. That direct exposure often irritates the nasal mucosa, producing burning, itching, or a stinging sensation and sometimes congestion or runny nose. Because of this local, route-specific effect, moderate to severe nasal irritation is the most characteristic adverse effect of nicotine nasal spray.

Headache and nausea can occur with nicotine products overall, but they are not as closely tied to the nasal route as nasal irritation is. Throat irritation can happen too, but it’s typically milder and less distinctive than the nasal irritation produced by this delivery method. If nasal irritation is troublesome, using proper technique, adjusting dose, or considering an alternative nicotine replacement therapy may help.