Which condition is listed as contraindication to varenicline?

• A. Psych illness (schizophrenia, agitation/aggression) or active alcohol use
• B. Controlled hypertension
• C. Mild asthma
• D. Chronic kidney disease

Answer: (A)

Varenicline carries a notable risk of neuropsychiatric effects, such as mood changes, agitation, aggression, and even suicidality in some individuals. Because these risks are especially problematic for people with preexisting psychiatric conditions or for those actively using alcohol, these situations are listed as contraindications. In other words, the safety concerns around mental health status and ongoing alcohol use make initiating varenicline inappropriate. The other conditions mentioned (controlled hypertension, mild asthma, chronic kidney disease) do not constitute contraindications on their own, though they may require consideration of safety or dosing in some cases.