Which of the following is a major contraindication to bupropion?

• A. Controlled hypertension
• B. History of seizures
• C. Non-smoker status
• D. Recent use of nicotine replacement therapy

Answer: (B)

Bupropion carries a risk of lowering the seizure threshold, so it is avoided in people who have a history of seizures. This risk is dose-dependent and can precipitate convulsions in someone with a prior seizure disorder or predisposition, making a seizure history the most important contraindication. The other scenarios described do not inherently prevent use: controlled hypertension may require monitoring but is not an absolute contraindication, being a non-smoker doesn’t disqualify its use for mood symptoms, and recent nicotine replacement therapy doesn’t by itself rule out bupropion.