Which option reflects the correct lead time for starting nortriptyline before quitting?

• A. 2-4 Weeks Before
• B. 1-2 Days Before
• C. On the Day Of
• D. 6-8 Weeks After

Answer: (A)

To get the most benefit from nortriptyline as an aid to quitting, it needs time to build up in the body and for the dose to be adjusted to minimize side effects while maximizing its effect on withdrawal and cravings. Nortriptyline takes a bit to reach therapeutic levels and to help smooth the transition off nicotine, so starting a window of two to four weeks before the quit date gives you that ramp-up period. Beginning only one to two days before, on the day of quitting, or after quitting wouldn’t provide the needed pre-quit support and the medication wouldn’t be at effective levels when cravings hit hardest. That’s why the recommended lead time is two to four weeks prior to quitting.